CYP1A1 *2B and *4 polymorphisms are associated with lung cancer susceptibility in Mexican patients
| Autor: | A M Puebla-Prez, M R Flores-Marquez, G M Zniga-Gonzlez, Martha Patricia Gallegos-Arreola, R. Troyo-Sanroman, L.E. Figuera-Villanueva, G Morgn-Villela |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Lung Neoplasms Adolescent Genotype Clinical Biochemistry Population Polymorphism Single Nucleotide Pathology and Forensic Medicine Risk Factors Cytochrome P-450 CYP1A1 Humans Medicine Lung cancer education Mexico Aged DNA Primers Aged 80 and over education.field_of_study Lung Base Sequence business.industry Homozygote Smoking Respiratory disease Cancer DNA Neoplasm Middle Aged medicine.disease Lung cancer susceptibility Phenotype medicine.anatomical_structure Amino Acid Substitution Oncology Case-Control Studies Multivariate Analysis Immunology Female Tobacco Smoke Pollution business |
| Zdroj: | ResearcherID Scopus-Elsevier |
| ISSN: | 0393-6155 |
| Popis: | CYP1A1 is a gene involved in the high aryl hydrocarbon hydroxylase -inducible phenotype, which is a genetically-determined variation among individuals that has been associated with lung cancer risk. More specifically, CYP1A1 *2B and *4 polymorphisms have been associated with high susceptibility to lung cancer among cigarette smokers.DNA was obtained from blood samples and we studied by PCR-RFLP the distribution of CYP1A1 *2B (n=248) and *4 (n=222) polymorphisms in healthy controls and 222 lung cancer patients from a Mexican population.Comparisons between groups showed an increased risk for lung cancer patients of *2B/*2B (18%; OR 7.6; 95% CI 3.0-19.2) and *4/ *4 genotypes (15%; OR 11.45; 95% CI 2.19-59.85) compared to the control group (1% for *2B/ *2B and 4.4% for *4/ *4). A significant association between lung cancer and homozygous *2B/ *2B passive smokers and *4/*4 ever (cigarettes) and passive smokers was also observed (p0.05). Multivariate analysis revealed an increased risk for the *2B/*2B genotype (OR 6.83), as well as for *4/*4 (OR 28.8).The results of the study indicate a significant association between *2B/*2B and *4/*4 genotypes and the risk of developing lung cancer among Mexicans. |
| Databáze: | OpenAIRE |
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