The clinical impact of antibacterial prophylaxis and cycling antibiotics for febrile neutropenia in a hematological malignancy and transplantation unit
| Autor: | G R Hobbs, Marcel P. Devetten, M Craig, S G Ericson, A R Sarwari, Aaron Cumpston |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Ofloxacin Neutropenia medicine.drug_class Antibiotics Drug Resistance Bacteremia Levofloxacin Transplantation Autologous Drug Administration Schedule Internal medicine medicine Humans Transplantation Homologous Gram-Positive Bacterial Infections Antibacterial agent Retrospective Studies Transplantation business.industry Retrospective cohort study Hematology Antibiotic Prophylaxis medicine.disease Survival Analysis Surgery Anti-Bacterial Agents Hematologic Neoplasms Drug Therapy Combination Female business Gram-Negative Bacterial Infections Febrile neutropenia medicine.drug Stem Cell Transplantation |
| Zdroj: | Bone marrow transplantation. 39(8) |
| ISSN: | 0268-3369 |
| Popis: | Febrile neutropenia is an expected complication during treatment of aggressive hematological malignancies and hematopoietic cell transplantation. We conducted a prospective cohort trial to determine the effects and safety of prophylactic fluoroquinolone administration, and rotation of empiric antibiotics for neutropenic fever in this patient population. From March 2002 through 2004, patients were treated with prophylactic levofloxacin during prolonged neutropenia, and a cycling schedule of empiric antibiotic therapy for neutropenic fever was initiated. The rates of bacteremia, resistance and complications were compared to a retrospective cohort of previously treated patients. The rate of gram-negative bacteremia decreased after the initiation of prophylactic levofloxacin (4.7 vs 1.8 episodes/1000 patient days, P |
| Databáze: | OpenAIRE |
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