Urodynamic findings in men operated on for an undescended testicle
| Autor: | R.S. Santti, T.T. Lahdes-Vasama, T.K. Streng, Teuvo L.J. Tammela, Juha Koskimäki, R.D. Fisch, E.A. Nilson |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Detrusor muscle Prostatic Diseases medicine.medical_specialty Urology Testicle Bladder outlet obstruction Prostate Cryptorchidism medicine Humans Testosterone Ultrasonography Gynecology medicine.diagnostic_test business.industry Estrogens Middle Aged Prostate-Specific Antigen Urinary Retention medicine.disease Urinary Bladder Neck Obstruction Undescended testicle Urodynamics Inguinal hernia medicine.anatomical_structure Transrectal ultrasonography business |
| Zdroj: | BJU International. 92:972-976 |
| ISSN: | 1464-410X 1464-4096 |
| DOI: | 10.1111/j.1464-410x.2003.04507.x |
| Popis: | OBJECTIVE To test the hypothesis that men with a history of undescended testicle have voiding problems similar to those in rodents exposed to excessive amounts of oestrogens during development, although the role of oestrogen in the failure of the human testicle to descend remains controversial. PATIENTS AND METHODS Thirteen men (mean age 45 years) previously operated on for an undescended testicle (testis-retention, TR group) and 12 age-matched men operated on for inguinal hernia or appendicitis (control group) participated in a urodynamic examination, transrectal ultrasonography (TRUS) of the prostate, and blood tests for hormones and prostate-specific protein. They also completed a questionnaire on urinary symptoms. RESULTS The free maximum flow rate was significantly lower and the detrusor pressure at maximum flow (PdetQmax) slightly higher in the TR than the control group. Three men in the TR group (and none of the controls) had bladder outlet obstruction (BOO), whereas voiding was not obstructed among 11 control men (and five men in the TR group). The hormone concentrations of the groups did not differ significantly but the prostates were significantly smaller in the TR group. The testosterone concentrations and the ratio between 17β-oestradiol (E2) and free testosterone (E2/fT) influenced prostate size significantly. An exploratory analysis suggested that E2/fT may influence the maximum detrusor pressure and PdetQmax. CONCLUSION Men born with an undescended testicle had smaller prostates but more often had BOO than did the controls. The results suggest that an imbalance between the actions of oestrogen and testosterone may influence the initiation and continuance of BOO among cryptorchid men. |
| Databáze: | OpenAIRE |
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