Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN): an update
Autor: | Mojakgomo Hendrick Motswaledi, Natalie Schellack, O. Mogole |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
business.industry
Steven-Johnsons syndrome (SJS) toxic epidermal necrolysis (TEN) granulysin supportive care hypersensitivity immunomodulating granulysin Public Health Environmental and Occupational Health Stevens johnson medicine.disease Toxic epidermal necrolysis supportive care immunomodulating Immunology steven-johnsons syndrome (sjs) Medicine Keratinocyte necrosis Granulysin hypersensitivity Family Practice business toxic epidermal necrolysis (ten) |
Zdroj: | South African Family Practice, Vol 58, Iss 5, Pp 57-59 (2016) Scopus-Elsevier South African Family Practice; Vol 58, No 5 (2016); 57-59 |
ISSN: | 2078-6204 2078-6190 |
Popis: | Stevens-Johnson syndrome (SJS) is a form of toxic epidermal necrolysis (TEN) a rare but life-threatening hypersensitivity reactions that affect the skin and mucous membranes. The most common triggers are drugs, but they can also be triggered by infections. Granulysin has been recently identified as the major molecule responsible for the widespread keratinocyte necrosis. Early identification and removal of causative agent is crucial in preventing progression of condition and reducing patient mortality. Supportive care is often recommended over immunomodulating treatments as it helps improve patient outcome.Keywords: Steven-Johnsons syndrome (SJS), toxic epidermal necrolysis (TEN), granulysin, supportive care, hypersensitivity, immunomodulating |
Databáze: | OpenAIRE |
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