Mesenchymal Stem Cells as Regulators of the Bone Marrow and Bone Components
| Autor: | V.B. Fernández-Vallone, C.H. Choi, C. Phillips, Vivian Labovsky, M.A. Amorós, Leandro Marcelo Martinez, Norma Alejandra Chasseing |
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| Přispěvatelé: | Bolontrade, Marcela Fabiana, Garcia, Mariana |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
OSTEOGENESIS
CIENCIAS MÉDICAS Y DE LA SALUD OSTEOCLASTOGENESIS Hematopoietic stem cell niche Mesenchymal stem cell BONE MARROW Clinical uses of mesenchymal stem cells Stem cell factor Patología Biology MESENCHYMAL STEM CELL CANCER Cell biology Medicina Básica medicine.anatomical_structure medicine Bone marrow Adult stem cell Homing (hematopoietic) Stem cell transplantation for articular cartilage repair |
| Zdroj: | Mesenchymal stromal cells as tumor stromal modulators |
| Popis: | Even though bone marrow mesenchymal stem cells and the “endosteal and vascular hematopoietic niche” have been an active area of study, the concept of the bone marrow/bone microenvironment harboring a niche for solid metastatic tumor cells was only recently considered. The hematopoietic stem cell niche that in some cases is thought to constitute the tumor niche shares many of the same structural and functional components, suggesting the possibility that the “hematopoietic and tumor niches” are one in the same. Mesenchymal stem cells, as well as the osteoblasts, are critical components for each of these niches and are important components for regulating cellular processes such as homing and migration, proliferation and survival, and quiescence and dormancy of tumor cells. Current understanding of mesenchymal stem cell properties may provide more insight to better defining the solid tumor niche, especially in the development of the bone marrow and bone “premetastatic niche.” Fil: Martinez, Leandro Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Labovsky, Vivian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Fernández Vallone, V. B.. Université Libre de Bruxelles; Bélgica Fil: Choi, H.. Central Texas Veterans Research Foundation; Estados Unidos Fil: Phillips, C.. Central Texas Veterans Research Foundation; Estados Unidos Fil: Amorós, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Chasseing, Norma Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina |
| Databáze: | OpenAIRE |
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