Detection of Helicobacter pylori CagA EPIYA in gastric biopsy specimens and its relation to gastric diseases
| Autor: | Ivy Bastos Ramis, Carlos Renan Varela Juliano, Otávio Leite Gastal, Priscila Cristina Bartolomeu Halicki, Júlia Silveira Vianna, Deise Machado dos Santos, Heitor Alberto Jannke, Renato Azevedo da Silva, Ana Lúcia Chaves, Lande Silva, Andrea von Groll, José Salomão Junior, Pedro Eduardo Almeida da Silva |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Biopsy Peptic Amino Acid Motifs Stomach Diseases Severity of Illness Index digestive system Gastroenterology Helicobacter Infections Young Adult Bacterial Proteins Disease severity Internal medicine medicine Gastric mucosa Humans CagA Gastric biopsy Aged Aged 80 and over Antigens Bacterial biology business.industry General Medicine Middle Aged Helicobacter pylori bacterial infections and mycoses biology.organism_classification Gastric Diseases digestive system diseases Infectious Diseases medicine.anatomical_structure bacteria Female Gastritis medicine.symptom business |
| Zdroj: | Diagnostic Microbiology and Infectious Disease. 83:89-92 |
| ISSN: | 0732-8893 |
| Popis: | CagA of Helicobacter pylori undergoes tyrosine phosphorylation in a region containing differing numbers of repeat sequences (EPIYAs), which can result in a modulation of the inflammatory response. This study investigated whether the presence of CagA EPIYA variations in strains of H. pylori that are positive for this region contributes to differing degrees of disease severity in the gastric mucosa. In this study, 157 H. pylori-positive patients were included, and of those, 40.8% (64/157) were infected with cagA-positive strains, which were assayed for the presence of CagA EPIYA-ABC, EPIYA-ABCC, and EPIYA-ABCCC. Peptic ulcers were significantly more prevalent in patients infected with strains containing CagA EPIYA-ABCC/ABCCC than in those with CagA EPIYA ABC strains (P=0.044). This suggests that the number of repetitions of EPIYA-C influences the development of gastroduodenal lesions, highlighting the importance and usefulness of evaluating the cagA gene sequence when making therapeutic intervention decisions in patients infected with H. pylori. |
| Databáze: | OpenAIRE |
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