Synthesis, Antibacterial, Antiurease, and Antioxidant Activities of Some New 1,2,4-Triazole Schiff Base and Amine Derivatives
| Autor: | Halil Ibrahim Ugras, Yasemin Sagkal, Huseyin Sahin, Bahar Bilgin Sökmen, Serpil Ugras, Nurhan Gümrükçüoğlu |
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| Přispěvatelé: | Fakülteler, Fen - Edebiyat Fakültesi, Kimya Bölümü, Sökmen, Bahar Bilgin |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Antioxidant
Hydrochloride medicine.medical_treatment Hydrazine Bioengineering Microbial Sensitivity Tests Urease inhibition activity Gram-Positive Bacteria Applied Microbiology and Biotechnology Biochemistry Antioxidants Structure-Activity Relationship Sodium borohydride chemistry.chemical_compound Schiff base 1 2 4-triazole Picrates Antioxidant activity Gram-Negative Bacteria medicine Structure–activity relationship Organic chemistry Furans Molecular Biology Schiff Bases Enzyme Assays Reduction Biphenyl Compounds Hydrazones 1 2 4-Triazole General Medicine Triazoles Anti-Ulcer Agents Anti-Bacterial Agents chemistry Hydrate Oxidation-Reduction Acyl hydrazone Biotechnology |
| Popis: | Sahin, Huseyin/0000-0002-6018-1494 WOS: 000348103100007 PubMed: 25342259 The acylhydrazone compound named ethyl N'-furan-2-carbonylbenzohydrazonate was synthesized by the condensation of ethyl benzimidate hydrochloride with furan-2-carbohydrazide. The treatment of the acylhydrazone with hydrazine hydrate afforded 4-amino-3-furan-2-yl-5-phenyl-1,2,4-triazole. The usage of this compound with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. The obtained products were identified by FT-IR, H-1-NMR, C-13-NMR. A series of compounds were evaluated for their antibacterial, antiurease, and antioxidant activities. The results showed that the synthesized new compounds had effective antiurease and antioxidant activities. |
| Databáze: | OpenAIRE |
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