Co-existence of myosin heavy chain I and IIa isoforms in human skeletal muscle fibres with endurance training
| Autor: | R. Betto, H. Klitgaard, O. Bergman, Bengt Saltin, G. Salviati, T. Clausen, Stefano Schiaffino |
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| Rok vydání: | 1990 |
| Předmět: |
Gene isoform
Gel electrophoresis Adult Electrophoresis medicine.medical_specialty biology Physiology Muscles Clinical Biochemistry Skeletal muscle Physical exercise Myosins Major histocompatibility complex Immunohistochemistry medicine.anatomical_structure Endocrinology Endurance training Physiology (medical) Internal medicine Myosin biology.protein medicine Physical Endurance Humans Receptor |
| Zdroj: | Pflugers Archiv : European journal of physiology. 416(4) |
| ISSN: | 0031-6768 |
| Popis: | The myosin heavy chain (MHC) composition of single fibres from m. vastus lateralis was analysed by one-dimensional electrophoresis and immunoblotting in three groups of young men with distinct difference in physical activity patterns. No major co-existence of MHC isoforms was found in the group with some daily physical activity. In the very sedentary group, however, 19 +/- 5% (P less than 0.05) of the fibres exhibited coexistence of MHC type IIa and IIb. Further, in the endurance trained group co-existence of MHC type I and IIa was manifested in 36 +/- 4% (P less than 0.05) of the fibres. Disuse and extreme usage of muscle both give rise to an elevation in co-expression of MHC isoforms in single muscle fibres but of markedly different combination of isoforms. |
| Databáze: | OpenAIRE |
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