Acceptance of antiviral treatment and enhanced service model for pregnant patients carrying hepatitis B
| Autor: | Ka Wang Cheung, P. W. Hui, Carmen Ng, CL Lai |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
HBsAg medicine.medical_specialty Hepatitis B virus Phosphorous Acids medicine.disease_cause Antiviral Agents Pregnancy medicine Blood test Humans Pregnancy Complications Infectious Retrospective Studies Hepatitis Hepatitis B Surface Antigens medicine.diagnostic_test business.industry Obstetrics Adenine Prenatal Care Hepatitis B Patient Acceptance of Health Care medicine.disease Infectious Disease Transmission Vertical DNA Viral Gestation Hong Kong Female business Viral load Maternal Serum Screening Tests |
| Zdroj: | Hong Kong medical journal = Xianggang yi xue za zhi. 26(4) |
| ISSN: | 1024-2708 |
| Popis: | INTRODUCTION A service model was established for pregnant women with positive screening results for hepatitis B surface antigen (HBsAg) at Queen Mary Hospital in Hong Kong. All women were offered a blood test for hepatitis B virus (HBV) DNA level during the first antenatal visit. Women with HBV DNA levels of ≥200 000 IU/mL received counselling from hepatologists regarding treatment with antenatal tenofovir disoproxil fumarate (TDF) 300 mg daily. METHODS This retrospective review included women attending our antenatal clinic who exhibited positive HBsAg screening results from 15 May 2017 to 31 December 2019. The proportions of women with positive HBsAg, DNA test acceptance, hepatological review, and TDF acceptance during pregnancy were reviewed. RESULTS In total, 375 (2.9%) of 13 082 pregnant women had positive HBsAg screening results. Blood tests for HBV DNA and hepatological reviews were offered to 273 women who had not undergone hepatological review prior to pregnancy; the acceptance rate was 97.8%. Sixty (22.6%) pregnant women were hepatitis B carriers with high viral loads of ≥200 000 IU/mL. Among 58 women with high viral loads, 57 received antenatal counselling regarding TDF and 56 (96.6%) agreed to take the drug; 92.9% of these 56 women had commenced TDF at or before 32 weeks of gestation. CONCLUSIONS This study indicated broad acceptance of HBV DNA tests by pregnant women. Triage allowed early review and commencement of antiviral medication. This service model serves as a framework for enhanced antenatal service to prevent mother-to-child-transmission in public maternity units. |
| Databáze: | OpenAIRE |
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