Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation
| Autor: | Oliver A. Garden, Michelle R. Goulart, Ying Wu, Yu-Mei Chang, Sarah Stewart, John G. Gribben, Laureen M. Peters, Anneliese Stell, Kelvin Kow, Nicholas J. Bacon, Dong Xia, Gerry Polton, Balazs Szladovits, Simon L. Priestnall, Michael Macfarlane, Eshita Sharma |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research oxidative phosphorylation Biology lcsh:RC254-282 Transcriptome 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases medicine B-cell lymphoma B cell Original Research animal model Germinal center lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Phenotype diffuse large B cell lymphoma 3. Good health Lymphoma Gene expression profiling 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis dog gene expression Cancer research metabolism Diffuse large B-cell lymphoma |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 10 (2020) |
| ISSN: | 2234-943X |
| Popis: | Gene expression profiling has revealed molecular heterogeneity of diffuse large B cell lymphoma (DLBCL) in both humans and dogs. Two DLBCL subtypes based on cell of origin are generally recognized, germinal center B (GCB)-like and activated B cell (ABC)-like. A pilot study to characterize the transcriptomic phenotype of 11 dogs with multicentric BCL yielded two molecular subtypes distinguished on the basis of genes important in oxidative phosphorylation. We propose a metabolic classification of canine BCL that transcends cell of origin and shows parallels to a similar molecular phenotype in human DLBCL. We thus confirm the validity of this classification scheme across widely divergent mammalian taxa and add to the growing body of literature suggesting cellular and molecular similarities between human and canine non-Hodgkin lymphoma. Our data support a One Health approach to the study of DLBCL, including the advancement of novel therapies of relevance to both canine and human health. |
| Databáze: | OpenAIRE |
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