Evaluation of commercial assays for vancomycin and aminoglycosides in serum: a comparison of accuracy and precision based on external quality assessment
| Autor: | John Fawcett Wilson, Caroline M Tobin, Alan C Davis |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Microbiology (medical)
Quality Control medicine.medical_specialty Urology Vancomycin External quality assessment medicine Tobramycin Humans Pharmacology (medical) Retrospective Studies Pharmacology medicine.diagnostic_test business.industry Aminoglycoside Reproducibility of Results Surgery Anti-Bacterial Agents Infectious Diseases Amikacin Therapeutic drug monitoring Gentamicin Netilmicin Reagent Kits Diagnostic business medicine.drug |
| Zdroj: | The Journal of antimicrobial chemotherapy. 52(1) |
| ISSN: | 0305-7453 |
| Popis: | Objective To compare the accuracy and precision of commercial assay techniques in the measurement of gentamicin, tobramycin, amikacin, netilmicin and vancomycin in serum. Methods Data from the measurement of 40 external quality assessment samples from 358 laboratories providing a therapeutic drug monitoring service were analysed. Results Significant differences between techniques in accuracy and precision were observed for all drugs. Coefficients of variation ranged from 4.1% to 9.8% for the aminoglycosides and from 6.7% to 11.7% for vancomycin. The percentage difference in measurements from the weighed-in drug concentration ranged from -10.1% to +4.0% for the aminoglycosides and from -3.5% to +5.7% for vancomycin. The Dade Behring Emit immunoassay was notable in producing significantly more outliers (>4 S.D. from the weighed-in concentration) than other techniques in the measurement of gentamicin, amikacin and vancomycin. Conclusions All assays performed to a satisfactory standard for measurement in non-renal patients, but none met the more stringent standards desirable for monitoring patients with renal impairment. |
| Databáze: | OpenAIRE |
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