Diels−Alder Cycloaddition Approach to Puupehenone-Related Metabolites: Synthesis of the Potent Angiogenesis Inhibitor 8-Epipuupehedione

Autor:	José Geraldo Lopes Ramos, Eduardo Cabrera, M. Hmamouchi, Rachid Chahboun, Ali Haidour, Hanane Bouanou, Enrique Alvarez-Manzaneda, Ramón Alvarez-Manzaneda, E. Alvarez
Rok vydání:	2007
Předmět:	Terpenes Chemistry Stereochemistry Xanthones Puupehenone Organic Chemistry Sclareol oxide 8-epipuupehedione Chemistry Organic Angiogenesis Inhibitors Cycloaddition Angiogenesis inhibitor Xanthenes Diels alder Organic chemistry Sesquiterpenes
Zdroj:	The Journal of Organic Chemistry. 72:3332-3339
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo0626663
Popis:	A new synthetic strategy toward puupehenone-related bioactive metabolites from sclareol oxide, based on a Diels-Alder cycloaddition approach, is described. Utilizing this, marine ent-chromazonarol and the potent angiogenesis inhibitor 8-epipuupehedione have been synthesized.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8630e79beb9363a3245d776f13181e8 https://doi.org/10.1021/jo0626663 Zobrazit plný text záznamu