The effects of prenatal and postnatal exposure to electromagnetic field on rat ovarian tissue
| Autor: | Acikgoz Burcu, Aksu Ilkay, Bagriyanik Husnu Alper, Kiray Amac, Kiray Muge, Ersoy Nevin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
animal structures
Offspring Health Toxicology and Mutagenesis Nitric Oxide Synthase Type II Physiology Ovary Toxicology Rats Sprague-Dawley 03 medical and health sciences Follicle Electromagnetic Fields 0302 clinical medicine Pregnancy Animals Medicine Reproductive system Adverse effect 030304 developmental biology 0303 health sciences Estradiol biology business.industry Public Health Environmental and Occupational Health medicine.disease Rats Nitric oxide synthase medicine.anatomical_structure Animals Newborn Prenatal Exposure Delayed Effects 030220 oncology & carcinogenesis biology.protein Female Follicle Stimulating Hormone business Hormone |
| Zdroj: | Toxicology and Industrial Health. 36:1010-1018 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233720973136 |
| Popis: | Exposure to an electromagnetic field (EMF) can have adverse effects on many organs and tissues, including the reproductive system. This study aimed to investigate the effects of EMF exposure during prenatal and postnatal periods on ovarian development in rat offspring. In this study, rat pups born from eight pregnant rats were used. EMF exposure was initiated on the first day of pregnancy and continued until the 42nd postnatal day. The blood and ovarian tissue samples of female offspring in sham and EMF groups were collected when they reached the age of 42 days. Follicle-stimulating hormone levels were significantly higher in the EMF group than in the sham group. Estradiol levels were significantly lower in the EMF group than in the sham group. Tissue-inducible nitric oxide synthase (iNOS) levels and expression were significantly greater in the EMF group than in the sham group. In the EMF group, congestion, bleeding areas, and degeneration of follicle structures were observed in ovarian tissue. The findings suggest that exposure to 50-Hz, 3-mT EMF used in this study during prenatal and postnatal periods may lead to impaired ovarian structure and function in female offspring. EMF may affect ovarian physiology by increasing iNOS levels and may lead to fertility disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|