Isoflurane and Propofol Contribute to Increasing the Antioxidant Status of Patients During Minor Elective Surgery
| Autor: | Kyung-Jin Yeum, Cristiana Maria Murbach Freire, Mariana Gobbo Braz, Guangwen Tang, Lorena M.C. Lucio, José Reinaldo Cerqueira Braz, Leandro Gobbo Braz, Daisy Maria Favero Salvadori |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp)Tufts University, Konkuk University |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Guanine Adolescent Anesthesia General medicine.disease_cause Antioxidants Young Adult chemistry.chemical_compound Outcome Assessment Health Care medicine Humans Prospective Studies Elective surgery Prospective cohort study Propofol Nasal Septum gamma-Tocopherol Isoflurane Inhalation business.industry Clinical Trial/Experimental Study General Medicine Middle Aged Rhinoplasty Oxidative Stress chemistry Elective Surgical Procedures Anesthesia Anesthetics Inhalation Anesthetic Uric acid Female business Anesthetics Intravenous Oxidative stress Research Article medicine.drug |
| Zdroj: | Medicine PubMed Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 0025-7974 |
| DOI: | 10.1097/md.0000000000001266 |
| Popis: | Made available in DSpace on 2015-12-07T15:31:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2015. Added 1 bitstream(s) on 2015-12-07T15:54:02Z : No. of bitstreams: 1 PMC4616612.pdf: 409692 bytes, checksum: c7a57c422d55de7e399e43bb089b4946 (MD5) Isoflurane is a volatile halogenated anesthetic used especially for anesthesia maintenance whereas propofol is a venous anesthetic utilized for anesthesia induction and maintenance, and reportedly an antioxidant. However, there are still controversies related to isoflurane-induced oxidative stress and it remains unanswered whether the antioxidant effects occur in patients under propofol anesthesia.Taking into account the importance of better understanding the role of anesthetics on oxidative stress in anesthetized patients, the present study was designed to evaluate general anesthesia maintained with isoflurane or propofol on antioxidant status in patients who underwent minimally invasive surgeries.We conducted a prospective randomized trial in 30 adult patients without comorbidities who underwent elective minor surgery (septoplasty) lasting at least 2 h admitted to a Brazilian tertiary hospital.The patients were randomly allocated into 2 groups, according to anesthesia maintenance (isoflurane, n = 15 or propofol, n = 15). Peripheral blood samples were drawn before anesthesia (baseline) and 2-h after anesthesia induction.The primary outcomes were to investigate the effect of either isoflurane or propofol anesthesia on aqueous plasma oxidizability and total antioxidant performance (TAP) by fluorometry as well as several individual antioxidants by high-performance liquid chromatography. As secondary outcome, oxidized genetic damage (7,8-dihydro-8-oxoguanine, known as 8-oxo-Gua) was investigated by the comet assay.Both anesthesia techniques (isoflurane or propofol) for a 2-h period resulted in a significant decrease of plasma α-tocopherol, but not other antioxidants including uric acid, carotenoids, and retinol (P > 0.05). Propofol, in contrast to isoflurane anesthesia, significantly increased (P |
| Databáze: | OpenAIRE |
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