Treatment of Advanced Coats' Disease With Combination Therapy of Laser Photocoagulation, Intravitreal Ranibizumab, and Sub-Tenon Methylprednisolone Acetate
| Autor: | Sergio Petroni, Gino Catena, Giancarlo Iarossi, Matteo Federici, Gaetano Zinzanella, Rosa Parrilla, Paola Valente, Luca Buzzonetti |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Pediatric Ophthalmology & Strabismus. 59:187-191 |
| ISSN: | 1938-2405 0191-3913 |
| DOI: | 10.3928/01913913-20211110-02 |
| Popis: | Purpose: To investigate the efficacy of combination therapy with laser photocoagulation, intravitreal ranibizumab, and sub-Tenon methylprednisolone acetate in patients presenting with advanced Coats' disease. Methods: This was a retrospective analysis of 16 patients who underwent laser photocoagulation combined with intravitreal ranibizumab and sub-Tenon methylprednisolone acetate between 2008 and 2017. The primary outcome was anatomic success and the secondary outcomes were globe preservation and final visual acuity. Results: The average age at surgery was 5.12 ± 2.7 years (range: 3 to 10 years). The mean follow-up time was 45.43 ± 29.01 months (range: 12 to 108 months). Of the 16 patients (16 eyes) reviewed, 6 patients had stage 3A and 10 patients had stage 3B Coats' disease. The mean number of applications was 10 (range: 4 to 18). Globe preservation was achieved in all patients. Final visual acuity outcomes were satisfactory: 20/20 to 20/50 in 2 patients, 20/60 to 20/100 in 1 patient, and 20/200 or worse in 13 patients. Conclusions: Intravitreal ranibizumab used in combination with laser photocoagulation and sub-Tenon methylprednisolone acetate could be an effective treatment option for patients with advanced Coats' disease. The combined therapy achieved anatomical success, globe preservation, and reasonable visual acuity outcomes. [ J Pediatr Ophthalmol Strabismus . 2022;59(3):187–191.] |
| Databáze: | OpenAIRE |
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