Modeling the release of curcumin from microparticles of poly(hydroxybutyrate) [PHB]
| Autor: | Berenice Vergara-Porras, Arturo Elias Aguilar-Rabiela, Ernesto M. Hernández-Cooper, José A. Otero |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Curcumin
Time Factors Diffusion equation Materials science Surface Properties Diffusion Kinetics Hydroxybutyrates 02 engineering and technology Biochemistry Polyhydroxybutyrate 03 medical and health sciences chemistry.chemical_compound Structural Biology Particle Size Molecular Biology 030304 developmental biology 0303 health sciences Heat balance Numerical Analysis Computer-Assisted General Medicine 021001 nanoscience & nanotechnology Microspheres Polyester Drug Liberation Models Chemical Chemical engineering chemistry Drug delivery 0210 nano-technology |
| Zdroj: | International Journal of Biological Macromolecules. 144:47-52 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2019.11.242 |
| Popis: | Polyhydroxybutyrate (PHB) is biodegradable and biocompatible polyester that has been recently used for developing different drug delivery systems (DDS). Microspheres as DDS, consist of a polymeric matrix with a diameter of 1–125 μm which contains a substance entrapped, and then released mainly through diffusion. In order to make DDS viable for commercial applications, it is essential to develop models that describe and predict the substance release kinetic. In this study, microspheres of PHB with curcumin entrapped were synthesized; the release of curcumin was studied and modeled. As a first approach, a physical model was introduced, in which mass transference was considered analogous to heat transference. The proposed model was based on local mass balance through the classical diffusion equation and total mass balance imposed through an integro-differential equation. The total mass balance introduced nonlinearities in the dynamics of the drug within the fluid; therefore, a semi-analytical approach based on the heat balance integral method was applied to solve the proposed model. Finally, by using the experimental rate of release of curcumin, the semi-analytical solutions to the proposed model were compared with the experimental release data, showing the importance of adding mass balance in the nonlinear mathematical model in order to describe more accurately the release kinetics. |
| Databáze: | OpenAIRE |
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