Predictive Value of First Posttreatment Imaging Using Standardized Reporting in Head and Neck Cancer
| Autor: | Jonathan J. Beitler, Mihir R. Patel, Derek Hsu, Suprateek Kundu, Patricia A. Hudgins, Falgun H. Chokshi, Ashley H. Aiken |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty 030218 nuclear medicine & medical imaging 03 medical and health sciences Young Adult 0302 clinical medicine Predictive Value of Tests Positron Emission Tomography Computed Tomography medicine Humans Treatment Failure Aged Proportional Hazards Models Retrospective Studies Aged 80 and over business.industry Squamous Cell Carcinoma of Head and Neck Head and neck cancer Middle Aged medicine.disease Head and neck squamous-cell carcinoma Predictive value Combined Modality Therapy Otorhinolaryngology Head and Neck Neoplasms Surgery Female Radiology business 030217 neurology & neurosurgery |
| Zdroj: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 161(6) |
| ISSN: | 1097-6817 |
| Popis: | The Neck Imaging Reporting and Data System (NI-RADS) is a standardized numerical reporting template for surveillance of head and neck squamous cell carcinoma (HNSCC). Our aim was to analyze the accuracy of NI-RADS on the first posttreatment fluorodeoxyglucose positron emission tomography/contrast-enhanced computed tomography (PET/CECT).Retrospective cohort study.Academic tertiary hospital.Patients with HNSCC with a 12-week posttreatment PET/CECT interpreted using the NI-RADS template and 9 months of clinical and radiologic follow-up starting from treatment completion between June 2014 and July 2016 were included. Treatment failure was defined as positive tumor confirmed by biopsy or Response Evaluation Criteria in Solid Tumors criteria. Cox proportional hazards models were performed.This study comprised 199 patients followed for a median of 15.5 months after treatment completion (25% quartile, 11.8 months; 75% quartile, 20.2 months). The rates of treatment failure increased with each incremental increase in NI-RADS category from 1 to 3 (4.3%, 9.1%, and 42.1%, respectively). A Cox proportional hazards model demonstrated a strong association between NI-RADS categories and treatment failure at both primary and neck sites (hazard ratio [HR], 2.60 and 5.22, respectively;Increasing NI-RADS category at the baseline posttreatment PET/CECT is strongly associated with increased risk of treatment failure in patients with HNSCC. |
| Databáze: | OpenAIRE |
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