Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism
| Autor: | Vassilios Papadopoulos, Enrico Campioli, Lucas Marques, Matthew Lau, Sunghoon Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Premature aging Genetic Markers Male medicine.medical_specialty Cyclohexanecarboxylic Acids Offspring lcsh:Medicine Gene Expression 010501 environmental sciences Biology Carbohydrate metabolism 01 natural sciences Article 03 medical and health sciences Plasticizers Internal medicine Testis medicine Animals Dicarboxylic Acids Testosterone lcsh:Science 0105 earth and related environmental sciences Multidisciplinary Leydig cell Testicular atrophy Reproduction lcsh:R Albumin medicine.disease 3. Good health Rats 030104 developmental biology medicine.anatomical_structure Endocrinology Glucose Reproductive Health In utero lcsh:Q Female Energy Metabolism Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017) |
| ISSN: | 2045-2322 |
| Popis: | In 2002, the plasticizer 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) was introduced in the European market as a substitute for endocrine-disrupting phthalates. We found that in utero exposure of rats to DINCH from gestational day 14 until parturition affected reproductive organ physiology and reduced circulating testosterone levels at post-natal day 60, indicating a long-term effect on Leydig cells of the testis. Metabolically, animals exhibited randomly increased serum glucose concentrations not associated with impaired glucose utilization. Analysis of liver markers in the serum showed a hepatic effect; e.g. reduced bilirubin levels and albumin/globulin ratio. At post-natal day 200, random appearance of testicular atrophy was noted in exposed offspring, and limited changes in other reproductive parameters were observed. In conclusion, DINCH exposure appears to directly affect Leydig cell function, likely causing premature aging of the testes and impaired liver metabolic capacity. These effects might be attenuated with physiologic aging. |
| Databáze: | OpenAIRE |
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