The effect of N-formylleurosine on DNA synthesis of Ehrlich ascites tumor
| Autor: | E. Pokorny, K. Szikla, I. Pályi, L. Holczinger |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Vinca
Cell Survival medicine.medical_treatment Mitosis Antineoplastic Agents Biology Thymidine Kinase Mice Multinucleate medicine Animals Neoplasm Carcinoma Ehrlich Tumor Vinca Alkaloids Metaphase Chemotherapy DNA synthesis DNA Neoplasm medicine.disease biology.organism_classification Oncology Mechanism of action Biochemistry Thymidine kinase medicine.symptom Thymidine |
| Zdroj: | European Journal of Cancer and Clinical Oncology. 19:1113-1119 |
| ISSN: | 0277-5379 |
| DOI: | 10.1016/0277-5379(83)90036-6 |
| Popis: | Some of the vinca alkaloids are well known and widely used in clinical practice, in spite of their numerous side-effects. For the elimination of untoward side-effects semi-synthetic alkaloids have been produced. This work reports on N-formylleurosine (N-F-Leu), one of these agents. Its antitumour activity is, in many respects, similar to that of other, presently used vinca alkaloids; it causes metaphase block, the appearance of multinucleated cells and polyploidization. In addition to these effects, N-F-Leu induces significant new phenomena, namely, changes in the activity of thymidine kinase, a key enzyme of DNA synthesis as well as in thymidine incorporation, and reduces the proportion of cells in S phase in a relatively short period of ti-me after treatmen: 24–29 hr. Based on these observations, the re-evaluation of the mechanism of action of vinca alkaloids has become possible. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|