Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release
| Autor: | Jing Quan, Sun Kan, Shi Meng, David H. Bremner, Li-Min Zhu, Hua-Li Nie, Xu Muru |
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| Rok vydání: | 2015 |
| Předmět: |
Coumaric Acids
Free Radicals Cell Survival Glycopolymer Nanofibers Lower critical solution temperature Polymerization Peanut Agglutinin chemistry.chemical_compound Drug Delivery Systems Colloid and Surface Chemistry Lectins Polymer chemistry Copolymer Caprolactam Humans MTT assay Physical and Theoretical Chemistry chemistry.chemical_classification Temperature Galactose Galactosides Surfaces and Interfaces General Medicine Polymer Electrospinning Monomer chemistry Chemical engineering Delayed-Action Preparations Nanofiber Polyvinyls HeLa Cells Biotechnology |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 135:209-216 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2015.07.041 |
| Popis: | The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release. |
| Databáze: | OpenAIRE |
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