Pure flat epithelial atypia (DIN 1a) on core needle biopsy: study of 60 biopsies with follow-up surgical excision

Autor: Vincent Lavoué, Claire Marie Roger, Mathieu Poilblanc, Nicolas Proust, Camille Monghal-Verge, Christine Sagan, Patrick Tas, Habiba Mesbah, Philippe Porée, Catherine Gay, Gilles Body, Jean Levêque
Přispěvatelé: CRLCC Eugène Marquis (CRLCC), Department of Gynecology, Service de Gynécologie CHU Anne de Bretagne, Centre René Gauducheau, CRLCC René Gauducheau, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Olympe de Gouges, CHU Bretonneau, Department of Pathology, Centre hospitalier universitaire de Nantes (CHU Nantes)
Jazyk: angličtina
Rok vydání: 2011
Předmět:
MESH: Carcinoma
Cancer Research
Pathology
Time Factors
MESH: Chi-Square Distribution
MESH: Mammary Glands
Human
030218 nuclear medicine & medical imaging
0302 clinical medicine
Breast cancer
Medicine
MESH: Aged
MESH: Middle Aged
medicine.diagnostic_test
Biopsy
Needle
Phyllodes tumor
Anatomical pathology
Hyperplasia
Middle Aged
MESH: Predictive Value of Tests
3. Good health
MESH: Precancerous Conditions
Oncology
030220 oncology & carcinogenesis
Female
France
Mammography
Adult
medicine.medical_specialty
MESH: Biopsy
Needle
MESH: Mammography
Breast Neoplasms
[SDV.CAN]Life Sciences [q-bio]/Cancer
03 medical and health sciences
Predictive Value of Tests
Biopsy
Carcinoma
Humans
Neoplasm Invasiveness
Mammary Glands
Human
Aged
Retrospective Studies
Chi-Square Distribution
MESH: Humans
MESH: Hyperplasia
MESH: Carcinoma
Intraductal
Noninfiltrating
business.industry
Surgical excision
MESH: Time Factors
MESH: Adult
MESH: Retrospective Studies
MESH: Neoplasm Invasiveness
Ductal carcinoma
medicine.disease
Flat epithelial atypia
MESH: France
Carcinoma
Intraductal
Noninfiltrating
Core needle biopsy
business
Precancerous Conditions
MESH: Female
MESH: Breast Neoplasms
Lobular Neoplasia
Zdroj: Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, Springer Verlag, 2011, 125 (1), pp.121-6. ⟨10.1007/s10549-010-1208-1⟩
ISSN: 0167-6806
1573-7217
DOI: 10.1007/s10549-010-1208-1⟩
Popis: International audience; Flat epithelial atypia (FEA) is recognized as a precursor of breast cancer and its management (surgical excision or intensive follow-up) remains unclear after diagnosis on core needle biopsy (CNB). The aim of this study was to determine the underestimation rate of pure FEA on CNB and clinical, radiological, and pathological factors of underestimation. 4,062 CNBs from 5 breast cancer centers, performed over a 5-year period, were evaluated. A CNB diagnosis of pure FEA was made in 60 cases (1.5%) (the presence of atypical ductal hyperplasia, lobular neoplasia, radial scars, phyllodes tumor, papillary lesions, ductal carcinoma in situ or invasive carcinoma at CNB were exclusion criteria), and subsequent surgical excision was systematically performed. The histological diagnosis was retrospectively reviewed using standardized criteria and the precise terminology of the World Health Organization by two pathologist physicians. At surgical excision, 6 (10%) ductal carcinoma in situ and 2 (3%) invasive carcinoma were diagnosed. The total underestimation rate was 13%. FEA was associated with atypical ductal hyperplasia in 10 (17%) cases and with lobular neoplasia in 2 (3%) at final pathology. Residual FEA was found in 14 (23%) cases. No clinical, radiological or pathological factors were significantly associated with underestimation. Our data highlight the importance of recognizing and diagnosing FEA in core needle biopsies. Thus, the presence of FEA on CNB, even in isolation, warrants follow-up excision.
Databáze: OpenAIRE
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