Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury
Autor: | Marco Capogrosso, Armin Curt, Eduardo Martin Moraud, Joachim von Zitzewitz, Silvestro Micera, Grégoire Courtine, Brigitte Schurch, Stefano Carda, Rubia van den Brand, Camille G. Le Goff, Jean-Baptiste Mignardot, Nicolas Fumeaux, Fabien Wagner, Jocelyne Bloch |
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Přispěvatelé: | University of Zurich, van den Brand, Rubia, Ecole Polytechnique Fédérale de Lausanne (EPFL), Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Balgrist University Hospital |
Rok vydání: | 2015 |
Předmět: |
medicine.medical_specialty
Neuroprosthetic technologies [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology medicine.medical_treatment Electric Stimulation Therapy 610 Medicine & health Translational research Walking Spinal cord injury Electrical neuromodulation Electrochemical neuromodulation Neurorehabilitation Orthopedics and Sports Medicine Rehabilitation 2732 Orthopedics and Sports Medicine Physical medicine and rehabilitation medicine Animals Humans Muscle Skeletal Spinal Cord Injuries Motor Neurons Neuronal Plasticity business.industry Electrochemical Techniques Prostheses and Implants Evoked Potentials Motor Functional recovery medicine.disease Spinal cord Neuromodulation (medicine) 3. Good health 2742 Rehabilitation medicine.anatomical_structure 10046 Balgrist University Hospital Swiss Spinal Cord Injury Center Augment business Neuroscience |
Zdroj: | Annals of Physical and Rehabilitation Medicine Annals of Physical and Rehabilitation Medicine, Elsevier Masson, 2015, 58 (4), pp.232-237. ⟨10.1016/j.rehab.2015.04.003⟩ |
ISSN: | 1877-0657 |
Popis: | International audience; Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients’ autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-based training paradigms restored supraspinal control of locomotion in rodent models of severe spinal cord injury. This treatment promoted extensive and ubiquitous remodeling of spared circuits and residual neural pathways. In four chronic paraplegic individuals, electrical neuromodulation of the spinal cord resulted in the immediate recovery of voluntary leg movements, suggesting that the therapeutic concepts developed in rodent models may also apply to humans. Here, we briefly review previous work, summarize current developments, and highlight impediments to translate these interventions into medical practice to improve functional recovery of spinal-cord-injured individuals. |
Databáze: | OpenAIRE |
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