Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury

Autor: Marco Capogrosso, Armin Curt, Eduardo Martin Moraud, Joachim von Zitzewitz, Silvestro Micera, Grégoire Courtine, Brigitte Schurch, Stefano Carda, Rubia van den Brand, Camille G. Le Goff, Jean-Baptiste Mignardot, Nicolas Fumeaux, Fabien Wagner, Jocelyne Bloch
Přispěvatelé: University of Zurich, van den Brand, Rubia, Ecole Polytechnique Fédérale de Lausanne (EPFL), Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Balgrist University Hospital
Rok vydání: 2015
Předmět:
medicine.medical_specialty
Neuroprosthetic technologies
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
medicine.medical_treatment
Electric Stimulation Therapy
610 Medicine & health
Translational research
Walking
Spinal cord injury
Electrical neuromodulation
Electrochemical neuromodulation
Neurorehabilitation
Orthopedics and Sports Medicine
Rehabilitation
2732 Orthopedics and Sports Medicine
Physical medicine and rehabilitation
medicine
Animals
Humans
Muscle
Skeletal
Spinal Cord Injuries
Motor Neurons
Neuronal Plasticity
business.industry
Electrochemical Techniques
Prostheses and Implants
Evoked Potentials
Motor
Functional recovery
medicine.disease
Spinal cord
Neuromodulation (medicine)
3. Good health
2742 Rehabilitation
medicine.anatomical_structure
10046 Balgrist University Hospital
Swiss Spinal Cord Injury Center
Augment
business
Neuroscience
Zdroj: Annals of Physical and Rehabilitation Medicine
Annals of Physical and Rehabilitation Medicine, Elsevier Masson, 2015, 58 (4), pp.232-237. ⟨10.1016/j.rehab.2015.04.003⟩
ISSN: 1877-0657
Popis: International audience; Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients’ autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-based training paradigms restored supraspinal control of locomotion in rodent models of severe spinal cord injury. This treatment promoted extensive and ubiquitous remodeling of spared circuits and residual neural pathways. In four chronic paraplegic individuals, electrical neuromodulation of the spinal cord resulted in the immediate recovery of voluntary leg movements, suggesting that the therapeutic concepts developed in rodent models may also apply to humans. Here, we briefly review previous work, summarize current developments, and highlight impediments to translate these interventions into medical practice to improve functional recovery of spinal-cord-injured individuals.
Databáze: OpenAIRE
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