| Autor: |
Iasmin Aparecida Cunha, Araújo, Renata Cristina, De Paula, Ceres Luciana, Alves, Karen Ferraz, Faria, Marco Miguel de, Oliveira, Gabriela Gonçalves Mendes, Takarada, Eliane Maritns Ferreira Abdias, Dias, Alaíde Braga de, Oliveira, Sydnei Magno da, Silva |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Experimental Parasitology. 242:108383 |
| ISSN: |
0014-4894 |
| DOI: |
10.1016/j.exppara.2022.108383 |
| Popis: |
The main form of control of leishmaniasis is the treatment, however various side effects and poor efficacy are associated with presently available drugs. The investigation of bioactive natural products for new antileishmanial drugs is a valid approach. The present study reports the in vitro efficacy of natural isoflavonoids and terpenes against Leishmania infantum and L. amazonensis and their cytotoxicity against HepG2 cells. L. infantum and L. amazonensis promastigotes were exposed to the terpenes kaurenoic acid, xylopic acid, and (-)-α-bisabolol and to the isoflavonoids (-)-duartin and (3R)-claussequinone for antileishmanial activity and to cytotoxicity to HepG2 cells. The most effective substance against both L. infantum and L. amazonensis species was (3R)-claussequinone (IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect