Non-alcoholic Wernicke encephalopathy: great masquerader
| Autor: | Chukwudumebi Okafor, Sarthak Soin, Lavanya Lanka, Manojna Nimmagadda |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Vomiting Cholecystitis Acute Gastroenterology 03 medical and health sciences Dysarthria 0302 clinical medicine Internal medicine Vertigo Weight Loss medicine Humans Wernicke Encephalopathy 030212 general & internal medicine Obesity Diplopia medicine.diagnostic_test biology business.industry food and beverages Brain Thiamine Deficiency Magnetic resonance imaging Nausea General Medicine Middle Aged medicine.disease biology.organism_classification Magnetic Resonance Imaging Diabetes Mellitus Type 2 Lactic acidosis Cholecystitis Thiamine Learning from Errors medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| Popis: | Thiamine is an important coenzyme, which is essential for metabolism and maintaining cellular osmotic gradient. Thiamine deficiency can cause focal lactic acidosis, alteration of the blood–brain barrier and the production of free radicals through cell death by necrosis and apoptosis. Wernicke encephalopathy (WE) is a clinical diagnosis. Cytotoxic and vasogenic oedema are the most typical neuroimaging findings of WE, presenting as bilateral symmetrical hyperintense signals on T2-weighted MR images. MRI is not necessary for the diagnosis of WE, but it can be helpful in ruling out alternative diagnosis. We present the case of an 61-year-old man with the history of class II obesity presenting with diplopia, dysarthria and vertigo, confirmed to be non-alcoholic WE. We aim to highlight the occurrence of WE in patients with large bowel resection though. Delay in diagnosis, particularly in obese individuals due to lack of suspicion, can lead to grim prognosis. |
| Databáze: | OpenAIRE |
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