Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination

Autor: Andrea Pizzi, Lorenzo Sori, Claudia Pigliacelli, Alfonso Gautieri, Clara Andolina, Greta Bergamaschi, Alessandro Gori, Pierre Panine, Antonio Mattia Grande, Markus B. Linder, Francesca Baldelli Bombelli, Monica Soncini, Pierangelo Metrangolo
Přispěvatelé: Politecnico di Milano, Department of Applied Physics, National Research Council of Italy, Xenocs SAS, Department of Bioproducts and Biosystems, Aalto-yliopisto, Aalto University
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Popis: Tallenna OA-artikkeli, kun julkaistu Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein exerting its role in the jumping and flight systems of insects. Elastic and resilient hydrogels are obtained, which also show self-healing behavior, thanks to the promoted non-covalent interactions that limit deformations and contribute to the structural recovery of the peptide-based hydrogel. In particular, halogen bonds may stabilize the β-sheet organization working as non-covalent cross-links between nearby peptide strands. Importantly, the unmodified peptide (i.e., wild type) does not show such properties. Thus, SDSY(3,5-Br)GAP is a novel minimalist peptide elastomer.
Databáze: OpenAIRE