In vivo metabolism of retrorsine and retrorsine-N-oxide
| Autor: | H. J. Segall, Michael W. Lamé, Pak Sin Chu |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities endocrine system Chromatography Gas endocrine system diseases Health Toxicology and Mutagenesis Pharmacology Biology Toxicology Rats Sprague-Dawley Excretion chemistry.chemical_compound medicine Animals Dicarboxylic Acids Pyrroles Senecio neoplasms Chromatography High Pressure Liquid Pyrrolizidine Alkaloids Alkaloid General Medicine Metabolism Rats Tritolyl Phosphates Plants Toxic Metabolic pathway chemistry Biochemistry Phenobarbital Pyrrolizidine Toxicity Retronecine medicine.drug |
| Zdroj: | Archives of Toxicology. 67:39-43 |
| ISSN: | 1432-0738 0340-5761 |
| DOI: | 10.1007/bf02072033 |
| Popis: | The in vivo metabolism and excretion of the urinary metabolites from the pyrrolizidine alkaloids (PAs), retrorsine (RET) and retrorsine-N-oxide (RET-NO) have been studied in rats. Isatinecic acid (INA), pyrrolic metabolites, N-oxides and retronecine accounted for 31.0, 10.3, 10.8 and 0.39% of the administered RET. Predosing rats with triorthocresyl phosphate (TOCP), had no effect on the excretion of pyrrolic metabolites and INA. Phenobarbital (PB) increased the excretion of both pyrrolic metabolites and INA with a corresponding decrease in the excretion of RET and N-oxides; the retronecine levels remained unaltered. When RET-NO was administered i.p., the urinary levels of pyrrolic metabolites, INA and RET were decreased relative to those treated with RET. The p.o. administration of RET-NO produced significantly higher levels of pyrrolic metabolites, INA and RET. These results suggest that esterase hydrolysis plays a minor role in the formation of INA and that a common metabolic pathway may exist between pyrrolic metabolites and INA formation. |
| Databáze: | OpenAIRE |
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