A one-year study on the pharmacodynamic profile of interferon- 1a in MS
| Autor: | Maria Spadaro, Francesca Bellomi, Patrizio Pasqualetti, C. Pozzilli, Guido Antonelli, Francesca Bagnato, Enrico Millefiorini, Carolina Scagnolari, Claudio Gasperini, Simona Galgani |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Neopterin Time chemistry.chemical_compound Multiple Sclerosis Relapsing-Remitting Recurrence immune system diseases Interferon Internal medicine medicine Humans Analysis of Variance Interferon β1a Chemotherapy Beta-2 microglobulin business.industry Multiple sclerosis Interferon beta-1a Interferon-beta medicine.disease Endocrinology chemistry Pharmacodynamics Immunology Linear Models Female Neurology (clinical) beta 2-Microglobulin business Follow-Up Studies medicine.drug |
| Zdroj: | ResearcherID |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.58.9.1409 |
| Popis: | Interferon (IFN)-beta1a induction of neopterin and beta2-microglobulin (beta2-MG) were evaluated over 1 year in patients with MS. Neopterin and beta2-MG levels peaked 24 to 48 hours after weekly injections of IFNbeta1a over the entire study period. Predose levels of neopterin decreased significantly, consistent with a long-term decrease in IFNgamma expression and macrophage activation during IFNbeta-1a treatment. Predose levels of beta2-MG increased, the significance of which is as yet unclear. |
| Databáze: | OpenAIRE |
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