Weekly monitoring of children with asthma for infections and illness during common cold seasons
| Autor: | Michael D. Evans, Woo Kyung Kim, Kathleen Roberg, James E. Gern, Wai Ming Lee, Tressa Pappas, Robert F. Lemanske, Fue Vang, L.E.P. Salazar, Jaime Olenec, Jack A. Bork |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Rhinovirus viruses Immunology Common Cold Monitoring Ambulatory medicine.disease_cause Polymerase Chain Reaction Severity of Illness Index Article Atopy Viral Respiratory Tract Infection Internal medicine Severity of illness medicine Immunology and Allergy Humans Child Respiratory Tract Infections Asthma Respiratory tract infections business.industry Common cold medicine.disease respiratory tract diseases medicine.anatomical_structure Virus Diseases Female Seasons business Respiratory tract |
| Zdroj: | Journal of Allergy and Clinical Immunology |
| ISSN: | 1097-6825 |
| Popis: | Background Exacerbations of childhood asthma and rhinovirus infections both peak during the spring and fall, suggesting that viral infections are major contributors to seasonal asthma morbidity. Objectives We sought to evaluate rhinovirus infections during peak seasons in children with asthma and to analyze relationships between viral infection and illness severity. Methods Fifty-eight children aged 6 to 8 years with asthma provided 5 consecutive weekly nasal lavage samples during September and April; symptoms, medication use, and peak flow were recorded. Rhinoviruses were identified by using multiplex PCR and partial sequencing of viral genomes. Results Viruses were detected in 36% to 50% of the specimens, and 72% to 99% of the viruses were rhinoviruses. There were 52 different strains (including 16 human rhinovirus C) among the 169 rhinovirus isolates; no strains were found in more than 2 collection periods, and all but 2 children had a respiratory tract infection. Virus-positive weeks were associated with greater cold and asthma symptom severity ( P P = .0002, respectively). Furthermore, virus-positive illnesses had increased duration and severity of cold and asthma symptoms and more frequent loss of asthma control (47% vs 22%, P = .008). Although allergen-sensitized versus nonsensitized children had the same number of viral infections, the former had 47% more symptomatic viral illnesses (1.19 vs 0.81 per month, P = .03). Conclusions Rhinovirus infections are nearly universal in children with asthma during common cold seasons, likely because of a plethora of new strains appearing each season. Illnesses associated with viruses have greater duration and severity. Finally, atopic asthmatic children experienced more frequent and severe virus-induced illnesses. |
| Databáze: | OpenAIRE |
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