A comparison of dehydration effects of V2-antagonist (OPC-31260) on the inner ear between systemic and round window applications
| Autor: | Akinobu Kakigi, Rie Nishioka, Daizo Taguchi, Teruhiko Okada, Taizo Takeda, Setsuko Takeda |
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| Rok vydání: | 2006 |
| Předmět: |
Receptors
Vasopressin Endocochlear potential Guinea Pigs Administration Oral Pharmacology Membrane Potentials otorhinolaryngologic diseases medicine Animals Humans Endolymphatic Hydrops Inner ear Endolymphatic hydrops Meniere Disease Cochlea Round window Chemistry Anatomy Benzazepines medicine.disease Sensory Systems Plasma osmolality Microscopy Electron stomatognathic diseases medicine.anatomical_structure Round Window Ear nervous system Systemic administration sense organs Antidiuretic Hormone Receptor Antagonists Meniere's disease |
| Zdroj: | Hearing Research. 218:89-97 |
| ISSN: | 0378-5955 |
| Popis: | V2-antagonist (OPC-31260 (OPC)) application to the scala tympani reduced endolymphatic hydrops. In the present study, we investigated whether systemic administration or local infusion via the round window (RW application) of OPC would be more suitable for clinical use. In Experiment 1, the increase ratios of the cross-sectional area of the scala media of experimentally induced endolymphatic hydrops were quantitatively assessed among four groups of non-OPC application, RW application of xanthan gum, systemic application of OPC and RW application of OPC. In Experiment 2, the effects of systemic and RW applications of OPC on plasma vasopressin (p-VP) concentrations and plasma osmolality (p-OSM) were investigated. In Experiment 3, endocochlear DC potential (EP) was measured in guinea pigs with the RW application of OPC. Electron microscopic observations of the stria vascularis and the hair cells were also made. Both systemic and RW applications of OPC significantly reduced endolymphatic hydrops. However, systemic application resulted in the distension of the Reissner's membrane in the non-operated ear, which seemed to be caused by elevated p-VP levels resulting from the systemic application of OPC. In contrast, RW application of OPC produced no apparent toxic effects in the inner ear, as indicated electrophysiological or morphological changes. Thus, drug delivery via the round window is more useful for the clinical application of OPC for medical decompression. |
| Databáze: | OpenAIRE |
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