The association between hypertension and colorectal cancer: a meta-analysis of observational studies
| Autor: | Yehuan Sun, Kun Xuan, Xin Chen, Haixia Liu, Tianming Zhao, Chenyu Sun, Akash S. Patel, Guangbo Qu |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Epidemiology Colorectal cancer MEDLINE Risk Assessment 03 medical and health sciences 0302 clinical medicine Internal medicine Female patient medicine Humans 030212 general & internal medicine business.industry Public Health Environmental and Occupational Health medicine.disease digestive system diseases Confidence interval Observational Studies as Topic Increased risk Oncology 030220 oncology & carcinogenesis Relative risk Meta-analysis Hypertension Observational study Female business Colorectal Neoplasms |
| Zdroj: | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 30(1) |
| ISSN: | 1473-5709 |
| Popis: | The relationship between hypertension and risk of colorectal cancer (CRC) is unclear. This meta-analysis aims to explore the association between them. Six databases were searched for studies published before August 2019. The pooled relative risk (RR) and 95% confidence intervals (CIs) were calculated to estimate the association between the hypertension and CRC risk. A total of 2841 potentially relevant articles were obtained, and 25 studies with a pooled 1.95 million participants were finally included in the meta-analysis. These results suggested a positive association between hypertension and risk of CRC with a pooled RR of 1.15 (95% CI: 1.08, 1.23). Male patients with hypertension had a 13% (95% CI: 1.06, 1.20) increased risk of CRC. The risk of colon cancer and rectal cancer in male patients was 1.17 (95% CI: 1.01, 1.36) and 1.35 (95% CI: 1.04, 1.74), respectively, while no association between hypertension and the risk of CRC in females was elucidated. This meta-analysis demonstrated that a positive association between hypertension and CRC exists, with male patients having a higher risk of developing CRC than female patients. |
| Databáze: | OpenAIRE |
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