BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoide
| Autor: | Francisca León B, Patricia González J, M. Fernanda Rozas, Lilian I Reyes S, Rodrigo Naves P |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
business.industry
medicine.medical_treatment T cell Autoimmunity General Medicine medicine.disease_cause stomatognathic diseases medicine.anatomical_structure Immune system Cytokine stomatognathic system immune system diseases hemic and lymphatic diseases Immunology Cytokines Medicine skin and connective tissue diseases business B-cell activating factor Receptor Autocrine signalling B cell activating factors B cell |
| Zdroj: | Revista médica de Chile v.134 n.9 2006 SciELO Chile CONICYT Chile instacron:CONICYT |
| ISSN: | 0034-9887 |
| DOI: | 10.4067/s0034-98872006000900014 |
| Popis: | BAFF (B cell activating factor belonging to the TNF family) is a cytokine implicated in the survival and maturation of peripheral B lymphocytes and T and B cell activation. BAFF binds to three different receptors: TACI, BCMA and BAFF-R, whose expression is restricted to B and T lymphocytes. BAFF and BAFF-R-deficient mice show a dramatic loss of peripheral B lymphocytes and a severely reduced immune response. In contrast, an enhanced BAFF expression leads to B cell hyperplasia and autoimmunity in mice. In vivo, administration of soluble decoy receptors for BAFF effectively decreases disease progression in various autoimmune mouse models. These evidences render BAFF as a potentially new therapeutic target. Elevated BAFF levels have been detected in the serum of patients with autoimmune diseases, such as Systemic Lupus Erythematosus, rheumatoid arthitis, Sjogren's syndrome, lymphoid cancers and HIV infection. In addition to BAFF receptors, malignant B cells abnormally express BAFF, which attenuates apoptosis through both autocrine and paracrine pathways. The data suggest that an increase in the expression of BAFF induces an enhanced B and T cell activation and the survival of pathologically active B cells. In this article, we review and discuss the participation of BAFF and its receptors in the immune response and its involvement in immunodeficiency, autoimmunity, infections and lymphoid cancers as well as the currently investigated therapies using BAFF antagonists in the treatment of these diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|