Biologic characteristics of premalignant breast disease
| Autor: | Karen S. Anderson, Maria Dolores Tabernero, Kimberly Cole |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Oncology
CA15-3 Cancer Research medicine.medical_specialty Breast Neoplasms Article Breast cancer Internal medicine Biomarkers Tumor Genetics Animals Humans Medicine Mammography skin and connective tissue diseases Neoplasm Staging Epigenomics medicine.diagnostic_test business.industry General Medicine medicine.disease Gene Expression Regulation Neoplastic Increased risk Biomarker (medicine) Female Breast disease DNA microarray business Precancerous Conditions |
| Zdroj: | Cancer Biomarkers. 9:177-192 |
| ISSN: | 1875-8592 1574-0153 |
| DOI: | 10.3233/cbm-2011-0187 |
| Popis: | Breast cancer is the second leading cause of cancer death in women in the United States. While mammography and breast magnetic resonance imaging (MRI) improve detection of early disease, there remains an Ullmet need for biomarkers for risk stratification, early detection, prediction, and disease prognosis. A number of early breast lesions, from atypical hyperplasias to carcinomas in situ, are associated with an increased risk of developing subsequent invasive breast carcinoma. The recent development of genomic, epigenomic, and proteomic tools for tissue biomarker detection, including array CGH, RNA expression microarrays, and proteomic arrays have identified a number of potential biomarkers that both identify patients at increased risk, as well as provided insights into the pathology of early breast cancer development. This chapter focuses on the detection and application of tissue and serum biomarkers for the identification and risk stratification of early breast cancer lesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|