Increased levels of angiopoietin-2 in induced sputum from smoking asthmatic patients
| Autor: | Shigenori Kyoh, Hiroshi Kanazawa, Yoshihiro Tochino, Toyoki Kodama, Kazuhisa Asai, Kazuto Hirata |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Vital capacity medicine.medical_specialty Pathophysiology of asthma Pathology medicine.drug_class Immunology Respiratory Mucosa Gastroenterology Angiopoietin-2 Capillary Permeability FEV1/FVC ratio Internal medicine Forced Expiratory Volume Angiopoietin-1 Immunology and Allergy Medicine Edema Humans Anti-Asthmatic Agents Respiratory system Asthma Bronchus Inhalation business.industry Smoking Beclomethasone Sputum respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure Corticosteroid Female Smoking Cessation business |
| Zdroj: | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 39(9) |
| ISSN: | 1365-2222 |
| Popis: | Summary Background Active cigarette smoking has detrimental effects on asthma morbidity and severity. Angiopoietin-1 has been shown to protect the microvessels against plasma leakage, whereas angiopoietin-2 enhances vascular permeability and subsequently induces airway mucosal oedema. Therefore, it is recently thought that angiopoietin-2 may contribute to the pathophysiology of asthma. Objective To determine whether angiopoietin-2 levels in the airways are associated with clinical profiles in smoking asthmatics. Methods We measured angiopoietin-1 and -2 levels in induced sputum in 35 normal controls (18 non-smokers and 17 smokers) and 49 asthmatics (24 non-smokers and 25 smokers) before and after inhaled beclomethasone dipropionate (BDP: 800 μg/day) therapy for 12 weeks. Results Angiopoietin-1 and -2 levels in induced sputum were significantly higher in asthmatics than in normal controls. Moreover, angiopoietin-2 levels were significantly higher in smoking asthmatics than in non-smoking asthmatics (P=0.0001). The airway vascular permeability index was also higher in smoking asthmatics than in non-smoking asthmatics. Moreover, the angiopoietin-2 level was positively correlated with the airway vascular permeability index (non-smoking asthmatics: r=0.87, P |
| Databáze: | OpenAIRE |
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