First Experimental Application of Multichannel Stimulation Devices for Cardiomyoplasty
| Autor: | Werner Girsch, Manfred Frey, W. Happak, Udo Losert, Herwig Thoma, Helmut Gruber, Winfried Mayr, Hermann Lanmüller |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pulmonary and Respiratory Medicine
Contraction (grammar) medicine.medical_treatment Technical failure Stimulation Isometric exercise 030204 cardiovascular system & hematology Surgical Flaps 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Assisted Circulation Cardiac Surgical Procedures Muscle fibre Electrodes Sheep Force level business.industry Muscles Latissimus dorsi muscle Hemodynamics Equipment Design Electric Stimulation 030228 respiratory system Surgery Cardiology and Cardiovascular Medicine business Cardiomyoplasty Muscle Contraction Biomedical engineering |
| Zdroj: | Journal of Cardiac Surgery. 6:252-258 |
| ISSN: | 0886-0440 |
| DOI: | 10.1111/jocs.1991.6.1s.252 |
| Popis: | The effect of long-term application of epineural electrodes to nerves was investigated in rat experiments. Neural damage reached a maximum of 6% shortly after implantation and decreased to 3% after 1 year. Impedance and threshold of epineural electrode were investigated in sheep experiments for up to 12 months. The mean impedance was in the range of 1 kohm, while the threshold less than 1 mA. The reduction in fatigue produced by multichannel stimulation was demonstrated by sequential isometric contractions of rectus muscles in sheep. The decrease in force was only 10% after 60 minutes of multichannel stimulation as compared to a reduction of 50% for single channel stimulation. Studies of cardiomyoplasty with single channel stimulation confirmed results reported by other investigators. In acute experiments with sheep, we demonstrated fiber-selective stimulation which led to isolated contraction of the left or right distal part or the right proximal part of the latissimus dorsi muscle. Potential advantages in the application of implantable multichannel stimulation devices as compared to single channel stimulation for cardiomyoplasty include: (1) fatigue-free stimulation at submaximal force level; (2) selection of hemodynamically effective electrode combinations; (3) potential for consecutive activation of muscle fiber groups, thereby allowing better simulation of the physiological contraction of the heart muscle; (4) redundancy of electrodes in case of technical failure or dislocation; and (5) stimulation of more than one muscle, if necessary. |
| Databáze: | OpenAIRE |
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