Radiosurgery for mesial temporal lobe epilepsy following ROSE trial guidelines — A planning comparison between Gamma Knife, Eclipse, and Brainlab
| Autor: | Garron Deshazer, David Cousins, Ganesh Narayanasamy, Jose Penagaricano, Wesley Garner, Edvaldo Galhardo, Steven M. Morrill, Demitre Serletis, Joshua Liu |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Organs at Risk
Quality Assurance Health Care medicine.medical_treatment Dose distribution Gamma knife 87.55.n epilepsy Gamma Knife Radiosurgery 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Planning method medicine Radiation Oncology Physics temporal lobectomy Humans Radiology Nuclear Medicine and imaging Instrumentation Eclipse epilepsy SRS Radiation business.industry Open surgery Radiotherapy Planning Computer-Assisted 87.55.kh Radiotherapy Dosage ROSE trial Volumetric modulated arc therapy Epilepsy Temporal Lobe 030220 oncology & carcinogenesis Practice Guidelines as Topic epilepsy Radiotherapy Intensity-Modulated Nuclear medicine business 87.53.Ly Mesial temporal lobe epilepsy |
| Zdroj: | Journal of Applied Clinical Medical Physics |
| ISSN: | 1526-9914 |
| Popis: | Purpose This study aims to compare stereotactic radiosurgery (SRS) planning of epilepsy that complies with Radiosurgery or Open Surgery for Epilepsy (ROSE) guidelines in GammaKnife, non‐coplanar conformal (NCC) plan in Eclipse, dynamic conformal arc (DCA) plan in Brainlab, and a volumetric modulated arc therapy (VMAT) plan in Eclipse. Methods Twenty plans targeting Mesial temporal lobe epilepsy (MTLE) was generated using GammaKnife, Eclipse with 20 NCC beams, Brainlab with 5 DCA, and Eclipse VMAT with 4 arcs observing ROSE trial guidelines. Multivariate analysis of variance and Wilcoxon signed‐rank test were used to compare dosimetric data of the plans and perform pairwise comparison, respectively. Results The plans obeyed the recommended prescription isodose volume (PIV) within 5.5–7.5 cc and maximum doses to brainstem, optic apparatus (OA) of 10 and 8 Gy, respectively, for a prescription dose of 24 Gy. The volumes of the target were in the range 4.0–7.4 cc. Mean PIV, maximum dose to brainstem, OA were 6.5 cc, 10 Gy, 7.9 Gy in GammaKnife; 7.2 cc, 6.1 Gy, 4.5 Gy in Eclipse NCC; 7.2 cc, 6.4 Gy, 5.7 Gy in Brainlab DCA; and 5.2 cc, 8.4 Gy, 6.1 Gy in Eclipse VMAT plans, respectively. Multivariate analysis of variance showed significant differences among the 4 SRS planning techniques (P‐values |
| Databáze: | OpenAIRE |
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