Different Neuroendocrine Mechanisms Regulate the Acute Pituitary Follicle-Stimulating Hormone Response to Orchidectomy and Ovariectomy
| Autor: | Peter V. Berardo, Louis V. Depaolo |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Time Factors medicine.drug_class Ovariectomy Endocrinology Diabetes and Metabolism Gonadotropin-releasing hormone Peptide hormone Biology Gonadotropin-Releasing Hormone Cellular and Molecular Neuroscience Follicle-stimulating hormone chemistry.chemical_compound Endocrinology Anterior pituitary Pituitary Gland Anterior Internal medicine Prohibitins medicine Animals Estrous cycle Sex Characteristics Endocrine and Autonomic Systems Rats Inbred Strains Luteinizing Hormone Rats medicine.anatomical_structure Castration chemistry Phenobarbital Female Follicle Stimulating Hormone Gonadotropin Luteinizing hormone Orchiectomy hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neuroendocrinology. 43:511-518 |
| ISSN: | 1423-0194 0028-3835 |
| DOI: | 10.1159/000124575 |
| Popis: | The following experiments were conducted to determine whether a sex difference exists in neuroendocrine mechanisms controlling acute pituitary follicle-stimulating hormone (FSH) responses to castration. Adult male rats and 4-day cycling female rats on diestrus 1 were injected intraperitoneally with either phenobarbital sodium (PhB, 80 mg/kg b.w.) or vehicle at 08:00 h. Following a blood collection at 10:00 h, rats given PhB or vehicle were either sham castrated or castrated under ether. Additional blood samples were obtained, and supplemental PhB or vehicle injections were given at 3, 8, 13, 18, and 24 h after castration. Administration of PhB to male rats completely prevented acute increases in plasma luteinizing hormone (LH) and FSH levels after orchidectomy (ORDX). In contrast, PhB treatment did not prevent initial rises in plasma FSH levels at 8 h after ovariectomy (OVX) and only partially suppressed OVX-induced increases in plasma FSH levels between 13 and 24 h. Plasma LH levels were not elevated by 24 h after OVX. In order to specifically evaluate the role of LH-releasing hormone (LHRH) in mediating the PhB-sensitive rises in gonadotropins after castration, groups of male rats and female rats on estrus were injected subcutaneously with 400 micrograms of a potent LH-RH antagonist (ALHRH) or oil at 12:00 h. At 10:00 h on the next morning, an initial blood sample was taken, and all rats were castrated under ether. Additional blood samples were taken at times indicated in the previous experiment.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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