Redox regulation of ER and mitochondrial Ca2+ signaling in cell survival and death
| Autor: | György Hajnóczky, Suresh K. Joseph, Michael P. Young, David M. Booth |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell Survival Physiology Endoplasmic Reticulum Redox Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animals Humans Calcium Signaling Receptor Molecular Biology chemistry.chemical_classification Reactive oxygen species Cell Death Inositol trisphosphate Mitochondrial calcium uniporter Cell Biology Mitochondria Cell biology 030104 developmental biology chemistry Calcium Oxidation-Reduction 030217 neurology & neurosurgery Ca2 signaling |
| Zdroj: | Cell Calcium |
| ISSN: | 0143-4160 |
| Popis: | Physiological signaling by reactive oxygen species (ROS) and their pathophysiological role in cell death are well recognized. This review focuses on two ROS targets that are key to local Ca(2+) signaling at the ER/mitochondrial interface - notably, inositol trisphosphate receptors (IP(3)Rs) and the mitochondrial calcium uniporter (MCU). Both transport systems are central to molecular mechanisms in cell survival and death. Methods for the measurement of the redox state of these proteins and for the detection of ROS nanodomains are described. Recent results on the redox regulation of these proteins are reviewed. |
| Databáze: | OpenAIRE |
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