Experimental allergic encephalomyelitis: Changes in growth and proliferation within the draining lymph node following injection of basic encephalitogenic protein in Freund's complete adjuvant
| Autor: | Lodin Z, Jana Krásenská, Miroslav Holub, Vladimír Mareš, Ivan Matous-Malbohan |
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| Rok vydání: | 1974 |
| Předmět: |
Pathology
medicine.medical_specialty Encephalomyelitis Autoimmune Experimental Cell division Experimental allergic Encephalomyelitis Freund's Adjuvant Guinea Pigs Immunology Biology Tritium medicine Animals Lymph node Myelin Sheath DNA synthesis Myelin Basic Protein Organ Size Hyperplasia medicine.disease Complete adjuvant Rats medicine.anatomical_structure Rats Inbred Lew Autoradiography Cattle Female Immunization Lymph Nodes Lymph Cell Division Thymidine |
| Zdroj: | Cellular Immunology. 12:350-362 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/0008-8749(74)90091-4 |
| Popis: | Changes in wet weight, dry mass, and DNA synthesis of draining lymph nodes from rats injected with encephalitogenic basic protein in Freund's complete adjuvant (FCA) were studied. Lymph nodes of rats injected with encephalitogenic basic protein in FCA show accelerated enlargement from the second up to the fourth day after injection, as compared to lymph nodes of rats injected with FCA alone, or with nonencephalitogenic basic protein in FCA. The greatest difference in lymph node weight was found on the fourth day. At this time cell division is higher in the group injected with encephalitogenic protein in FCA than in the group injected with FCA alone. However, the increased division of cells in situ cannot account, in and by itself, for the enlargement of the lymph node which was observed. It is concluded that migration of lymphocytes into the lymph node makes a substantial contribution to the hyperplasia of the lymph node. The results suggest that accelerated lymph node enlargement may be specific, at least in part, for induction of experimental allergic encephalomyelitis. |
| Databáze: | OpenAIRE |
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