Inhibition efficacy of extracellular carbonic anhydrases in glioblastoma depends on the glycolytic phenotype

Autor:	Proescholdt, MA, Stoerr, EM, Lohmeier, A, Brawanski, AT
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	ddc: 610 610 Medical sciences Medicine
Zdroj:	68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS); 20170514-20170517; Magdeburg; DOCMi.13.03 /20170609/
DOI:	10.3205/17dgnc448
Popis:	Objective: Malignant gliomas metabolize glucose preferably by glycolysis which is in accordance to the Warburg effect. This induces a high demand of glucose combined with a significant lactic acid load. Surprisingly, the intracellular pH has been demonstrated to be slightly alkaline in these tumors.[for full text, please go to the a.m. URL] 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d841d0d5d52382b33ee52734d5feefd0 Zobrazit plný text záznamu