Serotonin 5-HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder
| Autor: | Avner Elizur, Aliezer A. Bar-Nathan, Malka Israeli, Shlomo Bruch, Nir Essar, Anat Biegon |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Internal medicine medicine Humans Platelet skin and connective tissue diseases Maprotiline Receptor Depression (differential diagnoses) 5-HT receptor Aged Pharmacology Psychiatric Status Rating Scales Depressive Disorder Mood Disorders 5-HT2 receptor Cell Membrane Middle Aged Endocrinology Receptors Serotonin Antidepressant Female sense organs Serotonin Ketanserin Psychology Biomarkers medicine.drug Clinical psychology |
| Zdroj: | Psychopharmacology. 102(1) |
| ISSN: | 0033-3158 |
| Popis: | Serotonin receptors of the 5-HT2 type were studied on platelet membranes from 15 patients suffering from major depression. Receptor binding and clinical state (assessed by the Hamilton and Beck rating scales) were examined in a drug free state upon admission and after 1 and 3 weeks of treatment with the antidepressant maprotiline (MPT). 5-HT2 receptor binding changed in correlation with changes in the clinical state of the patients as judged by the rating scales. Since most patients showed a clinical improvement, the patients as a group exhibited a significant decrease in binding concomitant with a drop in depression scores. However, in those patients in whom there was no clinical change or an increase in depression scores, 5-HT2 receptor binding did not change or increased, respectively, thus resulting in a significant correlation between clinical changes and changes in binding. These results support the use of 5-HT2 receptors on platelets in evaluating depression and its treatment. |
| Databáze: | OpenAIRE |
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