Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug‐Conjugated Stealth Mesenchymal Stem Cells

Autor: Dongwoo Khang, Yeon Kyung Lee, Jeong Hee Hong, Sang-Woo Kim, Jungil Choi, Sang-Hyun Kim, Jun-Young Park, Sun Jin Sym, Dong Un Lee, Young Ae Choi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Advanced Science
ISSN: 2198-3844
Popis: Lung cancer is a highly malignant tumor, and targeted delivery of anti‐cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors tissues. Using this approach, the current clinical dose of anti‐cancer drugs for the treatment of malignant lung tumors can be decreased by more than 100‐fold without triggering immunotoxicity.
Databáze: OpenAIRE
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