Spontaneous high-frequency (10-80 Hz) oscillations during up states in the cerebral cortex in vitro
| Autor: | Albert Compte, Gabriel D. Puccini, Vanessa F. Descalzo, Michael A. Harvey, Ramon Reig, Maria V. Sanchez-Vives |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Periodicity Time Factors Population Action Potentials Stimulation Biology Inhibitory postsynaptic potential Slice preparation Organ Culture Techniques In vivo Biological Clocks medicine Extracellular Animals Computer Simulation education Cerebral Cortex Neurons education.field_of_study General Neuroscience Pyramidal Cells Ferrets Neural Inhibition Articles medicine.anatomical_structure Cerebral cortex Excitatory postsynaptic potential Female Neural Networks Computer Nerve Net Neuroscience |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1529-2401 |
| Popis: | High-frequency oscillations in cortical networks have been linked to a variety of cognitive and perceptual processes. They have also been recorded in small cortical slices in vitro, indicating that neuronal synchronization at these frequencies is generated in the local cortical circuit. However, in vitro experiments have hitherto necessitated exogenous pharmacological or electrical stimulation to generate robust synchronized activity in the β/γ range. Here, we demonstrate that the isolated cortical microcircuitry generates β and γ oscillations spontaneously in the absence of externally applied neuromodulators or synaptic agonists. We show this in a spontaneously active slice preparation that engages in slow oscillatory activity similar to activity during slow-wave sleep. β and γ synchronization appeared during the up states of the slow oscillation. Simultaneous intracellular and extracellular recordings revealed synchronization between the timing of incoming synaptic events and population activity. This rhythm was mechanistically similar to pharmacologically induced γ rhythms, as it also included sparse, irregular firing of neurons within the population oscillation, predominant involvement of inhibitory neurons, and a decrease of oscillation frequency after barbiturate application. Finally, we show in a computer model how a synaptic loop between excitatory and inhibitory neurons can explain the emergence of both the slow ( This work was supported by the Spanish Ministry of Science and Innovation and the European Regional Development Fund. A.C. was supported by a Ramón y Cajal Research Fellowship of the Spanish Ministry of Science and is currently supported by the Researcher Stabilization Program of the Health Department of the Generalitat de Catalunya. |
| Databáze: | OpenAIRE |
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