Phylogenetic Analysis of isolates from new cases of HBV infection in Southern Italy
| Autor: | M. Gussio, Rosa Di Stefano, Antonio Craxì, Noemi Urone, Salvatore Magliocco, Vito Di Marco, Paola Pizzillo, Donatella Ferraro, Bruno Cacopardo |
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| Přispěvatelé: | Ferraro D, Urone N, Pizzillo P, Gussio M, Magliocco S, Cacopardo B, Craxì A, Di Marco V, Di Stefano, R |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Hepatitis B virus Settore MED/07 - Microbiologia E Microbiologia Clinica Genotype Biology medicine.disease_cause Microbiology Liver disease Epidemiology Genetics medicine Humans Molecular Biology Ecology Evolution Behavior and Systematics Phylogeny Aged Aged 80 and over Molecular Epidemiology Settore MED/12 - Gastroenterologia Molecular epidemiology Phylogenetic tree Sequence Analysis DNA Hepatitis B Middle Aged medicine.disease Virology Infectious Diseases Italy Immunology DNA Viral Female Viral hepatitis HBV genotypes molecular epidemiology Acute HBV infection phylogenetic analysis |
| Popis: | The level of endemicity of hepatitis B virus (HBV) infections in Italy is low and genotype D infections predominant. New HBV strains may however be introduced as a result of movements of people from regions of high endemicity. The aim of the present study was to determine whether strains from new cases of acute hepatitis B detected in southern Italy were due to endemic or new HBV strains. We studied 34 isolates from patients with acute hepatitis B infection, and 35 from chronic hepatitis B patients. A phylogenetic analysis of preS/S region was done by comparing the sequences from the acute and chronic cases with references sequences. The study showed that 44% of strain from acute hepatitis B patients were of genotype A, 53% of genotype D, and 3% of genotype E. The molecular analysis of isolates from acute hepatitis B patients from Sicily showed a change in the local epidemiology of this infection, with an increase in HBV/A infections and a clustering effect for HBV D2, possibly correlated to immigration. The introduction of new genotypes , could have an effect on HBV-correlated diseases due to the different association between genotype, liver disease and response to antiviral therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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