Non‐sedation—Does it improve health‐related quality of life after critical illness? A 3‐month follow‐up sub‐study of the NONSEDA trial
| Autor: | Helene K. Nedergaard, Hanne Irene Jensen, Palle Toft, Thomas Strøm, Hanne T. Olsen, Serkan Korkmaz, Catherine L. Hough |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Randomization Sedation medicine.medical_treatment mechanical ventilation Vitality law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Quality of life law Intensive care medicine 030212 general & internal medicine intensive care Mechanical ventilation business.industry 030208 emergency & critical care medicine General Medicine Mental health health-related quality of life Anesthesiology and Pain Medicine Physical therapy non-sedation medicine.symptom business |
| Zdroj: | Olsen, H T, Nedergaard, H K, Hough, C L, Korkmaz, S, Jensen, H I, Strøm, T & Toft, P 2021, ' Non-sedation—Does it improve health-related quality of life after critical illness? A 3-month follow-up sub-study of the NONSEDA trial ', Acta Anaesthesiologica Scandinavica, vol. 65, no. 4, pp. 481-488 . https://doi.org/10.1111/aas.13775 |
| ISSN: | 1399-6576 0001-5172 |
| DOI: | 10.1111/aas.13775 |
| Popis: | Background Critical illness is associated with severely impaired health-related quality of life (HRQoL) for years following discharge. The NONSEDA trial was a multicenter randomized trial on non-sedation versus sedation with a daily wake-up trial in critically ill, mechanically ventilated patients in Scandinavia. The aim of this sub-study was to assess the effect of non-sedation on HRQoL and degree of independence in activities in daily living (ADL) 3 months post-ICU. Methods All survivors were asked to complete the Medical Outcomes Study Short-Form 36 questionnaire (SF-36) and the Barthel Index 3 months post-ICU. To limit missing data, reminders were sent. If unsuccessful, telephone interviews could be used. Outcomes were the level of HRQoL and ADL-function in each group. All outcomes were assessed blinded. Results Of the 700 patients included 412 survived to follow-up. A total of 344 survivors participated (82%). Baseline data were equal between the two groups. Mean SF-36 scores for the non-sedated vs sedated patients were as follows: Physical Function 45 vs 40, P = .69, Bodily Pain: 61 vs 52, P = .81, General Health: 50 vs 50, P = .84, Vitality: 42 vs 44, P = .85, Social Function: 75 vs 63, P = .85, Role Emotional: 58 vs 50, P = .82, Mental Health: 70 vs 70, P = .89, Role Physical: 25 vs 28, P = .32, Physical Component Score: 38 vs 37, P = .81, Mental Component Score: 48 vs 46, P = .94, Barthel Index: 20 vs 20, P = .74. Conclusion Randomization to non-sedation neither improved nor impaired health-related quality of life or degree of independence in activities in daily living 3 months post-ICU discharge. |
| Databáze: | OpenAIRE |
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