Does prophylactic sotalol and magnesium decrease the incidence of atrial fibrillation following coronary artery bypass surgery: a propensity-matched analysis

Autor: A N Moloto, V Aerra, Manoj Kuduvalli, Antony D. Grayson, Brian M. Fabri, Arun K. Srinivasan, Aung Oo
Jazyk: angličtina
Předmět:
Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
lcsh:Surgery
Administration
Oral
Chemoprevention
Drug Administration Schedule
lcsh:RD78.3-87.3
Coronary artery bypass surgery
Magnesium Sulfate
Internal medicine
Atrial Fibrillation
Medicine
Humans
Hospital Mortality
Coronary Artery Bypass
Infusions
Intravenous
Aged
Probability
Retrospective Studies
business.industry
Incidence (epidemiology)
Incidence
Sotalol
Retrospective cohort study
Atrial fibrillation
General Medicine
lcsh:RD1-811
Middle Aged
medicine.disease
Cardiac surgery
Treatment Outcome
Cardiothoracic surgery
lcsh:Anesthesiology
Anesthesia
Propensity score matching
Cardiology
Drug Therapy
Combination
Female
Surgery
business
Cardiology and Cardiovascular Medicine
Anti-Arrhythmia Agents
medicine.drug
Research Article
Zdroj: Journal of Cardiothoracic Surgery, Vol 1, Iss 1, p 6 (2006)
Journal of Cardiothoracic Surgery
ISSN: 1749-8090
DOI: 10.1186/1749-8090-1-6
Popis: Background Atrial fibrillation can occur in up to 40% of patients undergoing coronary surgery. Methods We retrospectively analysed 103 consecutive coronary surgery patients under the care of one surgeon between April 2003 and September 2003. These patients received 40 mg of sotalol orally twice daily from the first post-operative day for 6 weeks and 2 g of magnesium intravenously immediately post surgery and on the first post-operative day. We developed a propensity score for the probability of receiving sotalol and magnesium after coronary surgery. 89 patients from the sotalol and magnesium group were successfully matched with 89 unique coronary surgery patients who did not receive either sotalol or magnesium with an identical propensity score. Results Preoperative characteristics were well matched between groups. There was no significant difference with respect to in-hospital mortality between groups (sotalol and magnesium 1.1% versus control 4.5%; p = 0.17). The incidence of atrial fibrillation in the sotalol and magnesium group was 13.5% compared to 27.0% in the controls (p = 0.025). Conclusion The combination of sotalol and magnesium can significantly reduce the incidence of post-operative atrial fibrillation following coronary surgery.
Databáze: OpenAIRE
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