Potential use of medicinal plants from Argentinean highland as agent anti‐photoaging
| Autor: | Iris Catiana Zampini, María Eugenia Orqueda, Karent Bravo, María Alejandra Moreno, Edison Osorio, María Inés Isla |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Ultraviolet Rays
Tyrosinase Photoaging Argentina Human skin Dermatology purl.org/becyt/ford/1 [https] 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Hyaluronidase medicine Humans purl.org/becyt/ford/1.6 [https] Medicinal plants chemistry.chemical_classification Plants Medicinal biology Traditional medicine Plant Extracts PHOTOAGING HYALURONIDASE biology.organism_classification medicine.disease Larrea Skin Aging Enzyme chemistry 030220 oncology & carcinogenesis ARGENTINIAN “JARILLAS” Collagenase COLLAGENASE ELASTASE medicine.drug |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 1473-2165 1473-2130 |
| Popis: | Background: The overexposure to sun ultraviolet (UV) radiation produce photoaging by effect of free radicals on lipid, protein, and nucleic acid or by direct activation of responsible enzymes of cleavage of extracellular matrix components (EMC). Aims: To develop new anti-photoaging agents, the anti-aging activity of four “jarillas” standardized extracts from Argentina (Zuccagnia punctata Cav., Larrea divaricata Cav., Larrea cuneifolia Cav., and Larrea nitida Cav.) were examined. Methods: The effect on the activity and expression of enzymes related to photoaging (collagenase, hyaluronidase, elastase, tyrosinase) and the antioxidant capacity of four “jarillas” extracts were examined. Results: The results suggest that “jarillas” extracts could protect EMC by inhibition of skin aging-related enzymes and suppression of the expression of metalloproteinases (MMP-1) in human skin fibroblasts from photoinduced damage. Modulation of MMP-1 expression induced by UV radiation in human skin cells could be associated, at least in part, with the ROS scavenging capacity of “jarilla” extracts. The extract of Z punctata was more active than Larrea species extracts in all the trials. The activity of Z punctata and Larrea extracts could be ascribed to chalcones and lignans, major constituents of “jarillas,” respectively. Conclusions: The results obtained would indicate the potential of these adapted species to live in arid zones of Argentina, exposed to high ultraviolet radiation in production of cosmetic products and justify the promotion of their sustainable use and the development of crops. Fil: Orqueda, Maria Eugenia. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina Fil: Moreno, María Alejandra. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina Fil: Zampini, Iris Catiana. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina Fil: Bravo, Karent. Universidad de Antioquia; Colombia Fil: Osorio, Edison. Universidad de Antioquia; Colombia Fil: Isla, Maria Ines. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina |
| Databáze: | OpenAIRE |
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