Topiramate relieves refractory intercostal neuralgia
| Autor: | Zahid H. Bajwa, Naveed Sami, Carol A. Warfield, Joshua Wootton |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty business.industry medicine.medical_treatment Chronic pain Carbamazepine Fructose Middle Aged medicine.disease Neuroma Surgery Anticonvulsant Opioid Topiramate Anesthesia Neuropathic pain Neuralgia medicine Humans Anticonvulsants Neurology (clinical) business Burning Pain medicine.drug |
| Zdroj: | Neurology. 52(9) |
| ISSN: | 0028-3878 |
| Popis: | Chronic pain is a well-known and troublesome complication following thoracotomy. Approximately 50% of patients experience some type of chronic post-thoracotomy pain syndrome (PTPS) even 2 years after thoracic surgery.1 Persistent pain after thoracotomy may indicate either a possible recurrence or progression of malignancy. However, a few patients have intense, sharp, shooting and burning pain, consistent with neuropathic pain located in the distribution of an intercostal nerve (intercostal neuralgia). This is not related to the malignancy, and can be due to nerve entrapment, neuroma formation, or persistent nerve irritation. Various centrally acting pharmacologic therapies are used to treat neuropathic pain, including antidepressants and anticonvulsants, in addition to opioid and nonopioid analgesics. Anticonvulsants that are reported to decrease neuropathic pain include phenytoin, carbamazepine, sodium valproate, and gabapentin.2-4 However, many patients either do not receive optimal pain relief or are unable to continue with these medications because of adverse effects. Topiramate … |
| Databáze: | OpenAIRE |
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