Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury
| Autor: | Silvestro Micera, Stéphanie P. Lacour, Ivan R. Minev, Eduardo Martin Moraud, Jerome Gandar, Quentin Barraud, Peter Detemple, Rubia van den Brand, Jocelyne Bloch, Andrea Mortera, Julie Kreider, Felix Schmitz, Grégoire Courtine, Nadia Dominici, N. V. Pavlova, Erwan Bezard, Laetitia Baud, Camille G. Le Goff, Silvio Kraus, Arthur Hirsch, Marco Capogrosso, Jack DiGiovanna, Leonie Asboth, Oliver Haverbeck, Pavel Musienko, Simone Duis, Nikolaus Wenger |
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| Přispěvatelé: | Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], International Paraplegic Foundation Chair in Spinal Cord Repair, Ecole Polytechnique Fédérale de Lausanne (EPFL), Department of Neurology with Experimental Neurology, Bertarelli Foundation Chair in Translational Neuroengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)- Center for Neuroprosthetics and Institute of Bioengineering, Motor Physiology Laboratory, Pavlov Insitute of Physiology, Laboratory of Neuroprosthetics, St Petersburg State University (SPbU), Laboratory of Neurophysiology and Experimental Neurorehabilitation, Children's Surgery and Orthopedic Clinic, Department of Nonpulmonary Tuberculosis, Institute of Physiopulmonology, The BioRobotics Institute, Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP), MOVE Research Insitute Amsterdam, Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Fondation Bertarelli Chair inTranslational Neuroscience and Neuroengineering [Lausanne], Center for Neuroprosthetics and Institute of Bioengineering, EPFL.-Fondation Bertarelli, Micromotive GmbH, Mainz, Germany, Université Paris Diderot - Paris 7 (UPD7), Fraunhofer Institute for Chemical Technology (Fraunhofer ICT), Fraunhofer (Fraunhofer-Gesellschaft), Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Motac Neuroscience, Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Publica, VU University Amsterdam, Research Institute MOVE, Coordination Dynamics |
| Rok vydání: | 2014 |
| Předmět: |
Genetics and Molecular Biology (all)
0301 basic medicine medicine.medical_specialty Neurology Time Factors [SDV]Life Sciences [q-bio] Medicine (all) Biochemistry Genetics and Molecular Biology (all) Biochemistry General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Gait (human) Lumbar SDG 3 - Good Health and Well-being Feedback Sensory medicine Animals Computer Simulation Muscle Skeletal Spinal cord injury Spinal Cord Injuries Motor Neurons Spinal Cord Stimulation Proprioception business.industry Motor control General Medicine X-Ray Microtomography Spinal cord medicine.disease Evoked Potentials Motor Neuromodulation (medicine) Biomechanical Phenomena Hindlimb Rats Kinetics 030104 developmental biology medicine.anatomical_structure Spinal Cord Rats Inbred Lew Evoked Potentials Motor/physiology Feedback Sensory/physiology Female Hindlimb/innervation Hindlimb/physiopathology Locomotion/physiology Motor Neurons/physiology Muscle Skeletal/innervation Muscle Skeletal/physiopathology Spinal Cord/physiology Spinal Cord Injuries/pathology Spinal Cord Injuries/physiopathology Spinal Nerve Roots/physiopathology business Spinal Nerve Roots 030217 neurology & neurosurgery Locomotion |
| Zdroj: | Nature Medicine Nature Medicine, Nature Publishing Group, 2016, 22 (2), pp.138-45. ⟨10.1038/nm.4025⟩ Nature Medicine, 22(2), 138-145. Nature Publishing Group Nature Medicine, vol. 22, no. 2, pp. 138-145 Wenger, N, Moraud, E M, Gandar, J, Musienko, P, Capogrosso, M, Baud, L, Le Goff, C G, Barraud, Q, Pavlova, N, Dominici, N, Minev, I R, Asboth, L, Hirsch, A, Duis, S, Kreider, J, Mortera, A, Haverbeck, O, Kraus, S, Schmitz, F, DiGiovanna, J, van den Brand, R, Bloch, J, Detemple, P, Lacour, S P, Bézard, E, Micera, S & Courtine, G 2016, ' Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury ', Nature Medicine, vol. 22, no. 2, pp. 138-145 . https://doi.org/10.1038/nm.4025 |
| ISSN: | 1546-170X 1078-8956 1744-7933 |
| DOI: | 10.1038/nm.4025⟩ |
| Popis: | International audience; Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the therapeutic approach to continuous stimulation applied to restricted spinal cord locations. Here we developed stimulation protocols that reproduce the natural dynamics of motoneuron activation during locomotion. For this, we computed the spatiotemporal activation pattern of muscle synergies during locomotion in healthy rats. Computer simulations identified optimal electrode locations to target each synergy through the recruitment of proprioceptive feedback circuits. This framework steered the design of spatially selective spinal implants and real-time control software that modulate extensor and flexor synergies with precise temporal resolution. Spatiotemporal neuromodulation therapies improved gait quality, weight-bearing capacity, endurance and skilled locomotion in several rodent models of spinal cord injury. These new concepts are directly translatable to strategies to improve motor control in humans. |
| Databáze: | OpenAIRE |
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