Osteoclastogenesis Inhibitory Polyketides from the Sponge-Associated Fungus Xylaria feejeensis
| Autor: | Cong-Cong Xu, Chunlin Zhuang, Jiao Li, Hua Tang, Yan-Ping Luo, Jie Wang, Keryea Soong, Li Su, Yalan Chou, Wen Zhang |
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| Rok vydání: | 2018 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization South china Magnetic Resonance Spectroscopy Stereochemistry Molecular Conformation Osteoclasts Bioengineering Fungus Inhibitory postsynaptic potential 01 natural sciences Biochemistry chemistry.chemical_compound Mice Ascomycota Osteogenesis Animals Molecular Biology biology 010405 organic chemistry Circular Dichroism Absolute configuration Biological activity Cell Differentiation General Chemistry General Medicine biology.organism_classification 0104 chemical sciences Porifera Mice Inbred C57BL 010404 medicinal & biomolecular chemistry Sponge chemistry Polyketides Molecular Medicine Xylaria feejeensis Macrolides Derivative (chemistry) |
| Zdroj: | Chemistrybiodiversity. 15(12) |
| ISSN: | 1612-1880 |
| Popis: | A new ten-membered macrolide (1) and a new α-pyrone derivative, (-)-annularin C (2), together with 14 known analogs (3-16) were isolated from the AcOEt extract of the fungus Xylaria feejeensis isolated from the South China Sea sponge Stylissa massa. The structures of the new compounds were elucidated by the spectroscopic analysis and by comparison with reported data. The absolute configuration was determined by the optical rotation and ECD experiments. In an in vitro test, compounds 1, 5 and 9 exhibited significant down-regulating activity of osteoclast cell differentiation at 0.5 and 1 μm. This is the first report of the fungus X. feejeensis from a marine sponge and of osteoclastogenesis inhibitory activity for the metabolites of these kinds. |
| Databáze: | OpenAIRE |
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