Carotid atheromatosis in nondiabetic renal transplant recipients: the role of prediabetic glucose homeostasis alterations
| Autor: | Silvia Velázquez, Domingo Marrero, José Manuel González-Posada, Domingo Hernández, Patricia Delgado, Aurelio Rodríguez, Julián Fernández, María José Vega, Esteban Porrini, Alejandra Alvarez, Eduardo Salido, L. Perez, Sergio Pitti, Desiré Luis, Armando Torres |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty medicine.medical_treatment Atheromatosis Risk Factors Internal medicine Diabetes mellitus medicine Glucose homeostasis Humans Transplantation Kidney business.industry Insulin Odds ratio Glucose Tolerance Test Middle Aged medicine.disease Atherosclerosis Kidney Transplantation medicine.anatomical_structure Endocrinology Carotid Arteries Glucose Intima-media thickness Cardiovascular Diseases Female business Tunica Intima Tunica Media Immunosuppressive Agents |
| Zdroj: | Transplantation. 84(7) |
| ISSN: | 0041-1337 |
| Popis: | BACKGROUND Prediabetic glucose homeostasis alterations are important cardiovascular risk factors but their role in renal transplant recipients (RTR) has not been established. METHODS In 172 RTRs without pretransplant or de novo diabetes, we measured carotid intima media thickness (c-IMT) and performed an oral glucose tolerance test (OGTT). RESULTS In multivariate analysis, age, hypertension and male sex were independently associated with a c-IMT in the third tertile. A significant interaction between gender and glucose homeostasis parameters was observed. Among male RTR, those with a c-IMT in the third tertile showed significantly higher plasma glucose and HbA1c levels (5+/-0.5% vs. 5.1+/-0.5% vs. 5.5+/-0.4%; P |
| Databáze: | OpenAIRE |
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